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Oral Etoposide Plus Antiretroviral Therapy Study Arm is Discontinued in the AIDS-Kaposi’s Sarcoma Study

Dr. Yarchoan receives the 2014 Abbott award in Clinical and Diagnostic Immunology

September 17, 2014
The 2014 awardees of the Cancer Detection, Diagnosis, and Treatment Technologies for Global Health funding opportunity have been announced

June 26, 2014
NCI’s investigators Hughes and colleagues describe a new paradigm in HIV reservoir research

February 6, 2013
NCI study suggests that the HPV prophylactic vaccine has the potential to prevent a substantial proportion of anal cancers in men who have sex with men (MSM)
Findings from a study of 363 HIV-infected MSM looking at HPV genotypes and anal disease prevalence revealed that HPV16 was the most common genotype overall and that up to 61% of high-grade anal intraepithelial neoplasia (HGAIN) cases could be attributed to HPV16/18. In addition, the fraction of HGAIN attributable to HPV16/18/31/33/45/52/58 increased to up to 89%. This study highlights the high prevalence of multiple HPV genotypes in HIV-infected MSM and suggests that the HPV prophylactic vaccines, the currently licensed and the investigational nonavalent, may play a role in preventing anal cancer in this population. Results of this study can be found in the Journal of Infectious Diseases. 2013; 207:392-401.

November 2012
Find out more about the new Visiting Scholars Program at the Frederick National Laboratory for Cancer Research

October 16, 2012
HIV Drug Blocks Growth of HER2-Positive Breast Cancer CellsNCI Cancer Bulletin, Volume 9, Number 20

April 19, 2012
Marjorie Robert-Guroff's intensive search for HIV vaccine
In the April Member Spotlight, the American Association for the Advancement of Science (AAAS) has recognized NCI Scientist Marjorie Robert-Guroff, for her contributions in HIV. Dr. Robert-Guroff is Chief of the Immune Biology of Retroviral Infection Section of the Vaccine Branch in the Center for Cancer Research. She oversees work on the possible treatment, prevention and diagnosis of HIV and AIDS. One of her main projects involved the development of an adenovirus recombinant vaccine for HIV infection.

November 9, 2011
Secretary, Hillary Clinton advocates for evidence-based efforts to defeat AIDS

November 7-8, 2011
The Proceedings of the 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research are now available on-line in Infectious Agents and Cancer. This conference, sponsored by OHAM, took place in Bethesda MD on November 7-8, 2011.

April 11, 2011
Distribution of cancers in the US HIV/AIDS population is shifting: New study finds an increase in non-AIDS defining cancers associated with aging is offsetting the decrease in AIDS-defining cancers.
As treatments for HIV/AIDS improve and patients are living longer, the distribution of cancers in this population has undergone a dramatic shift in the United States. While cases of the types of cancer that have been associated with AIDS progression have decreased, cases of other types of cancer are on the rise. These results, reported by scientists from the National Cancer Institute (NCI), part of the National Institutes of Health, and the Centers for Disease Control and Prevention, were published online April 11, 2011, in the Journal of the National Cancer Institute. For more information on these findings, please visit: http://www.cancer.gov/newscenter/pressreleases/2011/HIVandCancerBurden

August 19, 2010
12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Program Book and selected Plenary Presentations
Permission has been granted by 2010 Conference presenters to have the following Plenary talk presentations published on this website.

Program Book

Selected Plenary talks

July 2010
The AIDS-Cancer Connection: Identifying Key Mechanisms in HIV-related Malignancy by Daniela S. Gerhard, Ph.D. – NCI Office of Cancer Genomics e-News, Issue 2

July 6, 2010
NCI Scientists Identify a New Inflammatory Syndrome in some persons with HIV/AIDS and KSHV Co-infection
OHAM Director Dr. Robert Yarchoan, Dr.Thomas Uldrick, Dr. Richard Little and NCI colleagues have identified a KSHV-associated IL-6 inflammatory syndrome resembling multicentric Castleman's disease in patients with HIV and KSHV co-infection

NCI scientists have identified a new inflammatory condition called interleukin-6 syndrome caused by Kaposi's sarcoma-associated herpesvirus (KSHV) in some people with HIV/AIDS. This syndrome will be added to three existing types of KSHV-linked illnesses in people with HIV/AIDS: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease (MCD). KSHV, also called human herpesvirus-8 (HHV-8), has some genetic sequences that are similar to the human genes that produce the cytokine interleukin-6 (IL-6), which is responsible for immune signaling between cells.

Patients with MCD develop high fevers, wasting, and other inflammatory symptoms that occur when tumor cells overproduce cytokines, in particular, KSHV-associated IL-6. In the new syndrome discovered by Thomas Uldrick, M.D., Richard Little, M.D., Robert Yarchoan, M.D, and co-workers at NCI, patients had inflammatory symptoms similar to those in MCD and high viral IL-6 levels, but they did not have MCD. Based on this finding, physicians should be on the lookout for this new KSHV-associated interleukin-6 syndrome in patients with both HIV and either KS or KSHV infections who develop unexplained fevers and other inflammatory symptoms. The study findings are reported online in Clinical Infectious Diseases and will appear in print in the August 1, 2010, issue of the journal.

April 26-27, 2010
The Proceedings of the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research are now available on-line in Infectious Agents and Cancer. This conference, sponsored by OHAM, took place in Bethesda MD on April 26-27, 2010.

October 20, 2009
Drs. Robert Yarchoan and Stuart LeGrice Receive NCI Director's Awards of Merit
At the 2009 NCI Director's Award Ceremony, Dr. Robert Yarchoan, Director of OHAM, and Dr. Stuart LeGrice, head of the Center of Excellence in HIV/AIDS and Cancer Virology, received Awards of Merit for leadership in promoting and supporting research in HIV/AIDS and HIV-associated malignancies at the National Cancer Institute.

A Summary of the Workshop on Merkel Cell Carcinoma - Basic, Epidemiologic, Translational and Clinical ResearchJournal of Clinical Oncology, Volume 27, Number 24
The article summarizes the research priorities on Merkel Cell Carcinoma (MCC) and the newly discovered human polyomavirus (MCPyV). This virus is found in approximately 80% of MCC.

The Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research are now available on-line in Infectious Agents and Cancer. This conference, sponsored by OHAM, took place in Bethesda, MD on October 6-7, 2008.

In Memoriam: William J. Harrington, Jr, MD – Journal of Acquired Immune Deficiency Syndromes

May 19, 2009
Marking a Memorable Moment in AIDS Research – NCI Cancer Bulletin, Volume 6,
Number 10

March 20, 2009
New Request for Applications Using American Recovery and Reinvestment Act Funds: "Exploratory Research in the Development of Vaccines for AIDS-associated Malignancies" It is listed as one of the Research and Research Infrastructure “Grand Opportunities” part of RFA-OD-09-004.

December 2, 2008
A Conversation with Dr. Sriram SubramaniamNCI Cancer Bulletin, Volume 5, Number 24

October 20, 2008
Researchers Identify Novel Type of Antibody that Potently Inhibits HIV InfectionNational Cancer Institute

July 2008
Combating HIV, One Tumor at a TimeCCR Connections Magazine, Volume 2, Number 1